Mesenchymal stem cells against sciatic pain. This is the research being conducted by the Ibiomed team at the University of León in collaboration with the Leonesa Pro Neurociencias Foundation. The study has been funded by the foundation for four years.
The research has shown that mesenchymal stem cells from adipose tissue can carry out immunomodulation in cells. These are the same cells that had been induced with inflammation using TNF (tumor necrosis factors).
In other words, it reduces inflammation of the sciatic nerve and pain in a rat. “We induce sciatica and treat it with these cells, and the rats show significant nerve regeneration,”. Explains Vega Villar, the lead researcher.
Pioneering Research Leadership: Ibiomed and the University of León
“At the forefront of this groundbreaking study is the Ibiomed team from the University of León. Spearheading innovative approaches, they’ve demonstrated the remarkable potential of mesenchymal stem cells derived from adipose tissue.”
“Collaborating seamlessly with the Leonesa Pro Neurociencias Foundation, Ibiomed’s team has diligently funded this four-year investigation. Their dedication reflects a commitment to advancing scientific understanding and paving the way for transformative treatments.”
“Their findings, published in the prestigious Spine Journal, underscore the significance of these institutions. Ibiomed and the Leonesa Pro Neurociencias Foundation stand as beacons of research excellence, contributing crucial insights to the field of sciatica treatment.”
“This collaborative effort not only bridges gaps in traditional treatments but also propels the study of neurogenic factors forward. The integration of Ibiomed’s expertise with the Foundation’s support represents a powerful alliance in the pursuit of effective and patient-centric solutions.”
Results
The results of the study are published in the Spine Journal, which specializes in neurosurgery, with significant scientific impact. The animal model used for research is a biomaterial. This material brings both TNF and cells into contact, localizing the injury for better analysis of the results.
Back pain is a highly prevalent condition. “Estimates suggest that at least 84% of individuals in the general population experience back pain at some point in their lives. Intervertebral disc degeneration (IVD) is one of the main causes of back pain.”
Surgical Interventions
Surgeries under anesthesia have shown that manipulating an uncompressed root does not produce pain. Similarly, sciatic pain can disappear despite the persistence of a hernia. Additionally, sciatica can occur without disc herniation.
“When disc degeneration occurs, it produces high levels of proinflammatory cytokines. There is also an increase in collagen and aggrecan degradation, and changes in disc tissue phenotypes occur.”
Traditional Treatments
Traditional treatments do not resolve the problem and have many side effects. Today, laboratories are researching new biological drugs, but they are still very expensive. None of the widely used biological agents leads to long-term pain remission without medication,” explains Vega Villar.
The use of stem cells has proven effective in regenerating one or more different cell types. The research used mesenchymal stem cells (MSCs). Which are the specific populations of cells in adult tissues that allow for periodic renewal or regeneration in case of tissue damage.
They come from bone marrow and adipose tissue, which are the two most common sources. “Adipose tissue cells, in particular, are considered a very attractive alternative to cells from bone marrow due to their abundant availability and excellent expansion and proliferation capacity.”
Stem Cells for Sciatica
This therapy, combined with the support of currently used treatments. Can improve the quality of life for patients with rheumatoid arthritis and disc herniation problems and minimize the long-term effects of these diseases.
“In our work, we propose the use of these cells to test their ability to block the release of proinflammatory cytokines and study if they have any activity on neurogenic factors, as a therapeutic alternative to traditional treatments and as a complement to the biological treatments currently in development.
Conclusion
“In conclusion, Ibiomed’s groundbreaking research unveils a promising frontier in sciatica treatment. The study demonstrates the remarkable potential of mesenchymal stem cells derived from adipose tissue.”
“Traditional treatments often fall short, and the team’s innovative approach introduces a new avenue for tackling back pain. Documented in the prestigious Spine Journal. This research not only sheds light on stem cell therapy but also paves the way for future advancements.”
“This study not only showcases the effectiveness of stem cell therapy but also holds the key to transforming lives. The integration of these findings into existing and upcoming treatments offers a beacon of hope for those suffering from sciatic pain.”
“In addressing neurogenic factors, Ibiomed’s research contributes to the ongoing pursuit of effective and lasting relief. In essence, the research signifies a transformative breakthrough, providing hope for improved treatments and the alleviation of sciatic pain.”
Be sure to visit our article What are stem cells?
